Geoff Cross 0770 2278385 geoffcross@video4medics.com

Jean Shanks Foundation/Pathological Society
Pathology Grand Round Virtual Lecture

FEBRUARY GRAND ROUND

Wednesday, 17th February –  09.00 to 10.00 GMT

From Digital Pathology to Somatic Mutations

Dr Moritz Gerstung and Dr Luiza Moore

Grand Round Partners – The Jean Shanks Foundation

The Jean Shanks Foundation was created by Dr Jean Shanks in 1986 when she floated JS Pathology PLC, a private pathology laboratory, onto the London Stock Exchange. The Foundation was set up to fund medical research and education, primarily to fund medical students wishing to have an extra research year at medical school – this research must have a pathology focus. Grants continue to be made to medical students but are also available for other projects that the trustees consider to be worthwhile.

The Foundation has grown considerably since its original inception and is now worth approximately £20m. Grants totalling in the region of £400,000 are given away annually.

LIVE STREAMING

Below is the Live Stream of today’s Grand Round, you will need to unmute to hear the audio.
You can adjust the quality of the stream plus take full screen if desired. 

Chat and Q&A

Below is the Chat and Q&A section for today’s session. Please enter your full name, tick box and Join.
Next, please click on the X to close blue box to access the Chat and Q&A.
Please note that we will be using ONLY the Q&A for this meeting. 

Grand Rounds – 2021 Schedule

FEBRUARY GRAND ROUND

Wednesday, 17th February –  09.00 to 10.00 GMT

From Digital Pathology to Somatic Mutations

Dr Moritz Gerstung and Dr Luiza Moore

Autism Mosaic

SPEAKERS

Dr Moritz Gerstung
Dr Moritz Gerstung

Research Group Leader - European Molecular Biology Laboratory EMBL

Moritz Gerstung leads a research group at EMBL-EBI investigating the underlying mechanisms of cancer development and seeking to understand the differences in therapy success and outcomes in different individuals. His team develops statistical models for relating different layers of genomic, molecular and clinical data to establish connections between genotype and phenotype, and tools to predict outcomes based on comprehensive, high-dimensional datasets. The group also explores the evolutionary dynamics of cancer. He has a PhD in Computational Biology from ETH Zurich (2012) and carried our postdoctoral work at the Wellcome Trust Sanger Institute (2012-2015). Moritz joined EMBL-EBI as a Research group leader in August 2015. In January 2021 Moritz started to lead a new division for AI in oncology at the German Cancer Research Centre (dkfz).

ORCID iD: 0000-0001-6709-963X

Dr Luiza Moore
Dr Luiza Moore

JSPS Intermediate Research Fellow at the Wellcome Sanger Institute

Luiza Moore is a JSPS Intermediate Research Fellow at the Wellcome Sanger Institute and  Consultant Histopathologist at Addenbrooke’s Hospital (Cambridge). In her PhD, she combined laser capture-microscopy and low-input DNA sequencing methods to study genomic alterations in normal human endometrium to gain a better understanding of how the tissue changes with age and in tumourigenesis. In her postdoctoral work, she is investigating somatic mutations and their transcriptomic consequences in endometrium and other tissues. She is a member of the Reproduction Group of the Human Cell Atlas and a partner of the Human Uterus Cell Atlas Consortium which aim to generate a single cell and spatial reference map of the human uterus. More recently, she was elected as a member of the Pathological Society of Great Britain and Ireland Research Committee.

CHAIR

Prof Adrienne Flanagan
Prof Adrienne Flanagan

President - Pathological Society

Adrienne received her medical degree from the Royal College of Surgeons in Ireland and undertook her PhD at the University of London in 1990 while she was a Medical Research Council Training Fellow at St George’s Hospital Medical School in London.

FEBRUARY GRAND ROUND RECORDING

Below is the edited recording of February’s Grand Round, you may need to unmute to hear the audio.
You can adjust the quality of the stream plus take full screen if desired. 

MARCH GRAND ROUND

Wednesday, 10th March –  09.00 to 10.00 GMT

Understanding Organisation of the Breast Tumour
Microenvironment by High-Dimensional Imaging

Dr Raza Ali, Cambridge

SPEAKER

Dr Raza Ali
Dr Raza Ali

CRUK Clinician Scientist Fellow, CRUK Cambridge Institute, University of Cambridge

Dr Ali trained in medicine and began specialty training in histopathology in South Wales before joining the Caldas group in Cambridge to conduct research in the molecular stratification of breast cancer, and developed methods for quantitative computational analysis of the intratumoural immune response. In 2017 he moved to Zurich where he investigated the interface between the somatic cancer genome and multidimensional tissue phenotypes using imaging mass cytometry within the Bodenmiller group. Dr Ali won a CRUK Clinician Scientist Fellowship in 2018 and will be starting as an independent group leader at the CRUK Cambridge Institute in early 2020.

CHAIR

Prof Adrienne Flanagan
Prof Adrienne Flanagan

President - Pathological Society

Adrienne received her medical degree from the Royal College of Surgeons in Ireland and undertook her PhD at the University of London in 1990 while she was a Medical Research Council Training Fellow at St George’s Hospital Medical School in London.

APRIL GRAND ROUND

Wednesday, 14th April –  09.00 to 10.00 GMT

TBA

Professor Ian Tomlinson, Edinburgh

SPEAKER

Dr Ian Tomlinson
Dr Ian Tomlinson

Cancer Genetics and Evolution - University of Edinburgh

Professor Tomlinson joined the University of Edinburgh in Autumn 2019 as Charles and Ethel Barr Chair of Cancer Research and became the Director of Edinburgh Cancer Research Centre (including Cancer Research UK  Edinburgh Centre) in January 2020. He was previously Director of the Institute of Cancer and Genomic Sciences at the University of Birmingham, having worked before that at the Cancer Research UK London Research Institute, University of Oxford and the Institute of Cancer Research. His research interests lie in discovering and functionally characterising cancer driver genes, especially germline variants that predispose to cancer. He also has a longstanding interest in cancer evolution, derived from his PhD project in population genetics, with a specific interest in the relative contributions of selection and mutation to cancer growth. Ian’s work focuses on colorectal cancer, but extends to several other cancer types. He is especially keen to integrate work across a variety of biomedical areas, including human patient cohorts and clinics, animal models of disease and biomathematics. 

CHAIR

Prof Adrienne Flanagan
Prof Adrienne Flanagan

President - Pathological Society

Adrienne received her medical degree from the Royal College of Surgeons in Ireland and undertook her PhD at the University of London in 1990 while she was a Medical Research Council Training Fellow at St George’s Hospital Medical School in London.

MAY GRAND ROUND

Wednesday, 12th May –  09.00 to 10.00 GMT

TBA

Professor Roberto Salgado

SPEAKER

Professor Roberto Salgado
Professor Roberto Salgado

Peter Mac Callum Cancer Center, Melbourne and GZA-ZNA Hospitals, Antwerp

Roberto Salgado is board certified in Anatomical Pathology since 2006. After his graduation as an Anatomical Pathologist he worked, besides as a clinical pathologist, also as a consultant Pathologist for the Breast International Group (BIG), and as a member of the Aurora Working Group helped develop the Aurora Molecular Screening Program for Metastatic Breast Cancer Patients. He was also a member of the Aurora Molecular Advisory Board of the Breast International Group. He’s a scientific collaborator of the Immuno-Task Force of the Breast International Group and an Honorary Research Fellow at the Division of Research at the Peter Mac Callum Cancer Center, Melbourne, Australia. Currently he’s chairing an International Consortium of Pathologists, namely the “International Immuno-Oncology Biomarkers Working Group that develops guidelines for the assessment of Immuno-Oncological Biomarkers in cancer. His strategic views on Oncology have been published in major international high impact factor journals including Nature Reviews Clinical Oncology, Nature Reviews Drug Discovery and Lancet Oncology. He has specific expertise in the Molecular Pathology of solid tumours, validation of biomarkers, innovative clinical trials incorporating genomics and development of biomarkers in immunotherapeutic trials, with a focus on Tumor Infiltrating Lymphocytes (TILs), with publications in Lancet Oncology, Nature, Nature Medicine and Journal of Clinical Oncology.

CHAIR

Prof Adrienne Flanagan
Prof Adrienne Flanagan

President - Pathological Society

Adrienne received her medical degree from the Royal College of Surgeons in Ireland and undertook her PhD at the University of London in 1990 while she was a Medical Research Council Training Fellow at St George’s Hospital Medical School in London.